Oleotide brings the same systems approach to formulation that Alchemy 21/12 is known for by considering the ecosystem of skin and the coordinated language it speaks. Cellular responsiveness, biological instruction, growth-factor signaling, structural organization, and barrier resilience each influence how skin maintains itself. The platform organizes technologies around these interconnected functions, creating an adaptable foundation for advanced topical treatments.
Modulate draws on senescence and cellular-stress research to support a rehabilitative approach to cellular behavior. Selected peptides address protein quality control and age-associated signaling of so-called "zombie cells," deploying an approach centered on cellular maintenance and resilience.
Instruct incorporates AI-assisted, collagen-directed messenger-RNA biotechnology designed to provide skin cells with instructions for collagen production. The approach combines sequence optimization and mRNA stabilization to support the use of those instructions by ribosomes—the cellular machinery that assembles proteins.
Signal brings together complementary growth-factor presentations, including oleosome-associated EGF and FGF-2 and a separately formulated recombinant EGF system. H2GLOW extends this communication framework with plant-derived, vesicle-associated exosomes.
Rebuild uses nine selected peptides to support matrix-related responses, collagen organization, junctional support and firmness-related pathways. These peptides target complementary aspects of skin's structural maintenance, including the organization of its supporting matrix and the connections that help maintain tissue cohesion, with the aim of improving visible firmness and resilience.
Restore and Defend establishes a foundation of ceramides, cholesterol, hydration and protective ingredients selected to support barrier function and resilience.
Together, these functions connect the platform's biological ambitions with Alchemy 21/12's barrier-first formulation philosophy. Its modular design allows their implementation and relative emphasis to evolve across different formulations.
The first product leveraging Oleotide is H2GLOW™, a freshly activated, dual-chamber, 14-day treatment. Two independently finished serums remain separate until activation, when they combine into a single 10 mL treatment for morning and evening application.
The dual-chamber architecture gives distinct biological preparations their own formulation environments before establishing a shared use phase. Growth-factor, peptide, RNA-associated and vesicle-associated technologies come together at activation within a compatible lipid and hydration foundation.
"Skin has a language, and we are learning to speak it," said Jennifer Valenti, founder of Alchemy 21/12. "Oleotide grew from a question that has shaped our research: how can we formulate around the way skin communicates, while respecting the barrier it depends on? H2GLOW is our first expression of that work and the beginning of a much larger vision."
H2GLOW is designed to reduce the appearance of wrinkles and improve skin firmness, texture, brightness, and tone through five coordinated functions spanning biological signaling, collagen-related instruction, structural organization, cellular-state support and barrier resilience. Its senescence-informed approach seeks to support more balanced cellular behavior and the conditions that sustain skin maintenance. The treatment is currently undergoing clinical evaluation.
H2GLOW will debut November 30, 2026, in a limited release of 200 units, with worldwide availability planned for 2027. Four additional products leveraging Oleotide are currently in research and development for release in 2027, extending the modular architecture into additional formulations and formats.
About Alchemy 21/12
Alchemy 21/12 is a California-based biotechnology company developing advanced skincare through cellular biology, formulation science, and a barrier-first philosophy. Its foundational method—Hydrate, Calm, Strengthen, and Signal—guides the development of daily skincare and intensive treatments.
